A novel one-pot strategy for fabrication of PEGylated MoS2 composites for pH responsive controlled drug delivery

摘要: Abstract Molybdenum disulfide (MoS2) is one of the most promising two-dimensional (2D) materials after graphene oxide. Its excellent properties make it for various applications, especially in field biomedicine owing to its small size, unique 2D morphology and photothermal conversion capacity. However, lack specific surface functional groups has still largely impeded their modification drug loading controlled release. In this paper, MoS2 sheets was modified by hydrazine groups, which could form dynamic hydrazone bonds with CHO-PEG doxorubicin hydrochloride (DOX) construct PEGylated based delivery systems. The structure, thermal stability, particle size related were characterized different equipment. characterization results confirm that these functionalized (MS-CO-NH) composites have been successfully prepared through formation bonds. On other hand, release MS-P-D loaded DOX showed pH responsive behavior, had a good sustained-release effect. More importantly, cell viability internalization MS-CO-NH material biocompatibility. composite cancer treatment effect, can transport into HepG2 cells slowly nucleus kill cells. view results, we believe new MoS2-based vector expected be candidate controlling intracellular treatment.