Thiol-containing compounds for the removal of elements from tissues and formulations therefor

摘要: Methods and pharmaceutical formulations for ameliorating heavy metal toxicity and/or oxidative stress are disclosed, comprising administering pharmaceutically effective amounts of ligands according to the present disclosure. The general structure: where R 1 comprises benzene, pyridine, pyridin-4-one, naphthalene, anthracene, phenanthrene or alkyl groups, 2 hydrogen, alkyls, aryls, a carboxyl group, carboxylate esters, organic groups biological 3 X lithium, sodium, potassium, rubidium, cesium, francium, thiophosphate, N-acetyl cysteine, mercaptoacetic acid, mercaptopropionic thiolsalicylate, n independently equals 1-10, m=1-6, Y polymers, silicas silica supported substrates, Z hydroxyl NH , HSO halogens, carbonyl substrates.