Composición química, actividad anti-Helicobacter pylori y antioxidante del aceite esencial de Satureja brevicalyx Epling "urqu muña"

摘要: --- The Helicobacter pylori is the main causal agent of gastritis, it conditions oxidative stress due to fact that produces free radicals. Satureja brevicalyx used treat gastrointestinal problems as gastritis. objective this work was characterize chemical components, anti-Helicobacter activity and antioxidant oil brevicalyx. Te reported a performance (1.80%v/p), optical rotation (- 2 + 4o), density (0,9047 g/mL) index refraction (1.475). By means CG-SM CG-FID elucidated 35 compounds at 97,1%: oxygenated monoterpens (74,8%) majority compound pulegone (27,2%), linalool (20,3%), menthone (11,1%), isomenthone (8,3%), cis-isopulegone (2,7%), trans-isopulegone (0,9%), carvacrol (0,6%), thymol (0,6%) α-terpineol (0,5%); sesquiterpenes hydrocarbons (16%), emphasizing biciclogermacrone (8,2%), β-caryophyllene (6,5%) bicicloelemene monoterpenic (4,1%), with p-cymene (2,0%), limonene (0,7%) γ-terpineno (0,6%); (1,5%), espatulenol (0,8%). method Artemia salina showed significant bioactivity, CL50 13,35 μg/mL, by Fixed Dose, in albinae mice shows DL50 655,26 mg/kg being slightly toxic. Diffusion Discs, has an antibacterial effect H. pylori, halo inhibition 33,33% comparation amoxiciline concentration 10 μg/mL; Microplacas, minimum inhibitory 1,00 bactericide 2,00 μg/mL. concentrations determined three models must be 10, 50 100 μg/mL: 1) inhibited radical DPPH 67.76, 75,33 86,84%, relation trolox which 80.59, 87,17 93,09%; 2) kidnapped hidroxile 28.95, 51,57 76,84%; 3) lipidic peroxidation 16.4x10-8, 9.8x10-8 8.5x10-8 moles x cm, 14.9x10-8, 8.0x10-8 7.5 x10-8 53.9x10-8 cm for negative control. structures S. justify its antioxidant. Key Words: brevicalyx, radicals,