Re-thinking miRNA-mRNA interactions: Intertwining issues confound target discovery
作者： Nicole Cloonan
关键词:
摘要: Despite a library full of literature on miRNA biology, core issues relating to target detection, biological effect, and mode action remain controversial. This essay proposes that the predominant mechanism direct is translational inhibition, whereas bulk effects are mRNA based. It explores several confounding discusses their impact dominance “miRNA seed” dogma exploration non-canonical binding sites. Finally, it makes comparisons between prediction transcription factor prediction, questions value characterizing sites based which nucleotides paired with an mRNA.
sci-hub.se 参考文章(111)
Alessia Baccarini, Brian D. Brown, Monitoring MicroRNA Activity and Validating MicroRNA Targets by Reporter-Based Approaches Methods in Molecular Biology. ,vol. 667, pp. 215- 233 ,(2010) , 10.1007/978-1-60761-811-9_15
Mikhail Spivakov, Spurious transcription factor binding: Non-functional or genetically redundant? BioEssays. ,vol. 36, pp. 798- 806 ,(2014) , 10.1002/BIES.201400036
Scott M. Hammond, Emily Bernstein, David Beach, Gregory J. Hannon, An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells Nature. ,vol. 404, pp. 293- 296 ,(2000) , 10.1038/35005107
Gabriel Kolle, Mirabelle Ho, Qi Zhou, Hun S. Chy, Keerthana Krishnan, Nicole Cloonan, Ivan Bertoncello, Andrew L. Laslett, Sean M. Grimmond, Identification of human embryonic stem cell surface markers by combined membrane-polysome translation state array analysis and immunotranscriptional profiling. Stem Cells. ,vol. 27, pp. 2446- 2456 ,(2009) , 10.1002/STEM.182
Wiebe Kruijer, Jonathan A. Cooper, Tony Hunter, Inder M. Verma, Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein Nature. ,vol. 312, pp. 711- 716 ,(1984) , 10.1038/312711A0
Lee P. Lim, Nelson C. Lau, Philip Garrett-Engele, Andrew Grimson, Janell M. Schelter, John Castle, David P. Bartel, Peter S. Linsley, Jason M. Johnson, Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs Nature. ,vol. 433, pp. 769- 773 ,(2005) , 10.1038/NATURE03315
Ulf Andersson Ørom, Anders H. Lund, Isolation of microRNA targets using biotinylated synthetic microRNAs Methods. ,vol. 43, pp. 162- 165 ,(2007) , 10.1016/J.YMETH.2007.04.007
A. K. White, M. VanInsberghe, O. I. Petriv, M. Hamidi, D. Sikorski, M. A. Marra, J. Piret, S. Aparicio, C. L. Hansen, High-throughput microfluidic single-cell RT-qPCR Proceedings of the National Academy of Sciences of the United States of America. ,vol. 108, pp. 13999- 14004 ,(2011) , 10.1073/PNAS.1019446108
Daehyun Baek, Judit Villén, Chanseok Shin, Fernando D. Camargo, Steven P. Gygi, David P. Bartel, The impact of microRNAs on protein output Nature. ,vol. 455, pp. 64- 71 ,(2008) , 10.1038/NATURE07242
Jidong Liu, Marco Antonio Valencia-Sanchez, Gregory J. Hannon, Roy Parker, MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies Nature Cell Biology. ,vol. 7, pp. 719- 723 ,(2005) , 10.1038/NCB1274