Oral administration of Allium sativum extract protects against infectious bursal disease in chickens

摘要: Garlic (Allium sativum, Liliaceae) has been safely used for more than 5000 years, and research on garlic extract is rapidly increasing because of its multiple biological functions. The in vivo effects oral administration mixture (GM, water-soluble extract) infectious bursal disease virus (IBDV)-infected specific pathogen free male white leghorn chicken were examined through histopathological, immunohistochemical, Western blot analyses, enzyme-linked immunosorbent assay. results confirmed the protective 5 mg$kg BW GM (Group GM1) lesions after IBDV infection. In particular, protein expression bursa decreased Group GM1, indicating that replication bursa. Furthermore, immunoglobulin Mand A-bearing B lymphocytes significantly increased 7 days post infection bursae GM1 (P< 0.01), suggesting offers moderate protection against cell destruction During infection, concentration interferon gamma (IFN-g) peaked earlier T (IBDV-exposed), demonstrating prompted production IFN-g to protect