Reduced expression of circRNA hsa_circ_0003159 in gastric cancer and its clinical significance.
作者： Mengqian Tian , Ruoyu Chen , Tianwen Li , Bingxiu Xiao
DOI: 10.1002/JCLA.22281
关键词:
摘要: Background Circular RNAs (circRNAs) play a crucial role in the occurrence of several diseases including cancers. However, little is known about circRNAs’ diagnostic values for gastric cancer, one worldwide most common mortality. Methods The hsa_circ_0003159 levels 108 paired cancer tissues and adjacent non-tumorous from surgical patients with were first detected by real-time quantitative reverse transcription-polymerase chain reaction. Then, relationships between expression clinicopathological factors analyzed. Finally, its value was evaluated through receiver operating characteristic curve. Results Compared tissues, significantly down-regulated tissues. What more, we found that negatively associated gender, distal metastasis, tumor-node-metastasis stage. Conclusions All results suggest may be potential marker cancer.
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