Randomized Phase III Study of Capecitabine Plus Oxaliplatin Compared With Fluorouracil/Folinic Acid Plus Oxaliplatin As First-Line Therapy for Metastatic Colorectal Cancer
作者： Jim Cassidy , Stephen Clarke , Eduardo Díaz-Rubio , Werner Scheithauer , Arie Figer
关键词:
摘要: Purpose To evaluate whether capecitabine plus oxaliplatin (XELOX) is noninferior to fluorouracil. folinic acid, and oxaliplatin (FOLFOX-4) as first-line therapy in metastatic colorectal cancer (MCRC). Patients and Methods The initial design of this trial was a randomized, two-arm, noninferiority, phase III comparison of XELOX versus FOLFOX-4. After patient accrual had begun, the trial design was amended in 2003 after bevacizumab phase III data became available. The resulting 2× 2 factorial design randomly assigned patients to …
pagesperso-orange.fr 参考文章(15)
Paulo M. Hoff, Rafat Ansari, Gerald Batist, John Cox, Walter Kocha, Mario Kuperminc, Jean Maroun, David Walde, Charles Weaver, Evelyn Harrison, Hans U. Burger, Bruno Osterwalder, Alfred O. Wong, Ralf Wong, Comparison of Oral Capecitabine Versus Intravenous Fluorouracil Plus Leucovorin as First-Line Treatment in 605 Patients With Metastatic Colorectal Cancer: Results of a Randomized Phase III Study Journal of Clinical Oncology. ,vol. 19, pp. 2282- 2292 ,(2001) , 10.1200/JCO.2001.19.8.2282
A. Grothey, K. Jordan, O. Kellner, C. Constantin, G. Dietrich, H. Kroening, L. Mantovani, C. Schlichting, H. Forstbauer, H.J. Schmoll, 295 Capecitabine plus irinotecan (CAPIRI) vs capecitabine plus oxaliplatin (CAPOX) as first-line therapy of advanced colorectal cancer (ACRC): updated results of a randomized phase II trial Ejc Supplements. ,vol. 1, ,(2003) , 10.1016/S1359-6349(03)90328-4
Rainer Porschen, Hendrik-Tobias Arkenau, Stephan Kubicka, Richard Greil, Thomas Seufferlein, Werner Freier, Albrecht Kretzschmar, Ullrich Graeven, Axel Grothey, Axel Hinke, Wolff Schmiegel, Hans-Joachim Schmoll, Phase III Study of Capecitabine Plus Oxaliplatin Compared With Fluorouracil and Leucovorin Plus Oxaliplatin in Metastatic Colorectal Cancer: A Final Report of the AIO Colorectal Study Group Journal of Clinical Oncology. ,vol. 25, pp. 4217- 4223 ,(2007) , 10.1200/JCO.2006.09.2684
E Van Cutsem, P M Hoff, P Harper, R M Bukowski, D Cunningham, P Dufour, U Graeven, J Lokich, S Madajewicz, J A Maroun, J L Marshall, E P Mitchell, G Perez-Manga, P Rougier, W Schmiegel, J Schoelmerich, A Sobrero, R L Schilsky, Oral capecitabine vs intravenous 5-fluorouracil and leucovorin: integrated efficacy data and novel analyses from two large, randomised, phase III trials British Journal of Cancer. ,vol. 90, pp. 1190- 1197 ,(2004) , 10.1038/SJ.BJC.6601676
Jim Cassidy, Josep Tabernero, Chris Twelves, René Brunet, Charles Butts, Thierry Conroy, Filippo Debraud, Arie Figer, Johannes Grossmann, Noriaki Sawada, Patrick Schöffski, Alberto Sobrero, Eric Van Cutsem, Eduardo Díaz-Rubio, XELOX (Capecitabine Plus Oxaliplatin): Active First-Line Therapy for Patients With Metastatic Colorectal Cancer Journal of Clinical Oncology. ,vol. 22, pp. 2084- 2091 ,(2004) , 10.1200/JCO.2004.11.069
A. de Gramont, A. Figer, M. Seymour, M. Homerin, A. Hmissi, J. Cassidy, C. Boni, H. Cortes-Funes, A. Cervantes, G. Freyer, D. Papamichael, N. Le Bail, C. Louvet, D. Hendler, F. de Braud, C. Wilson, F. Morvan, A. Bonetti, Leucovorin and Fluorouracil With or Without Oxaliplatin as First-Line Treatment in Advanced Colorectal Cancer Journal of Clinical Oncology. ,vol. 18, pp. 2938- 2947 ,(2000) , 10.1200/JCO.2000.18.16.2938
Werner Scheithauer, Gabriela V. Kornek, Markus Raderer, Birgit Schüll, Katharina Schmid, Erwin Kovats, Bruno Schneeweiss, Fritz Lang, Alfred Lenauer, Dieter Depisch, Randomized Multicenter Phase II Trial of Two Different Schedules of Capecitabine Plus Oxaliplatin as First-Line Treatment in Advanced Colorectal Cancer Journal of Clinical Oncology. ,vol. 21, pp. 1307- 1312 ,(2003) , 10.1200/JCO.2003.09.016
Mark V. Pauly, Is High and Growing Spending on Cancer Treatment and Prevention Harmful to the United States Economy Journal of Clinical Oncology. ,vol. 25, pp. 171- 174 ,(2007) , 10.1200/JCO.2006.08.7536
Eduardo Díaz-Rubio, Jose Tabernero, Auxiliadora Gómez-España, Bartomeu Massutí, Javier Sastre, Manuel Chaves, Alberto Abad, Alfredo Carrato, Bernardo Queralt, Juan José Reina, Joan Maurel, Encarnación González-Flores, Jorge Aparicio, Fernando Rivera, Ferrán Losa, Enrique Aranda, Phase III study of capecitabine plus oxaliplatin compared with continuous-infusion fluorouracil plus oxaliplatin as first-line therapy in metastatic colorectal cancer: final report of the Spanish Cooperative Group for the Treatment of Digestive Tumors Trial. Journal of Clinical Oncology. ,vol. 25, pp. 4224- 4230 ,(2007) , 10.1200/JCO.2006.09.8467
Patrick Therasse, Susan G. Arbuck, Elizabeth A. Eisenhauer, Jantien Wanders, Richard S. Kaplan, Larry Rubinstein, Jaap Verweij, Martine Van Glabbeke, Allan T. van Oosterom, Michaele C. Christian, Steve G. Gwyther, New Guidelines to Evaluate the Response to Treatment in Solid Tumors JNCI: Journal of the National Cancer Institute. ,vol. 92, pp. 205- 216 ,(2000) , 10.1093/JNCI/92.3.205