Development and bioanalytical validation of a liquid chromatographic-tandem mass spectrometric (LC-MS/MS) method for the quantification of the CCR5 antagonist maraviroc in human plasma
作者： Joshua F. Emory , Lauren A. Seserko , Mark A. Marzinke
DOI: 10.1016/J.CCA.2014.02.008
关键词:
摘要: Background Maraviroc is a CCR5 antagonist that has been utilized as viral entry inhibitor in the management of HIV-1. Current clinical trials are pursuing maraviroc drug efficacy both oral and topical formulations. Therefore, order to fully understand pharmacokinetics, sensitive method required quantify plasma concentrations.
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