Putting Infection Dynamics at the Heart of Chagas Disease

摘要: In chronic Trypanosoma cruzi infections, parasite burden is controlled by effective, but nonsterilising immune responses. Infected cells are difficult to detect because they scarce and focally distributed in multiple sites. However, advances detection technologies have established a link between persistence the pathogenesis of Chagas heart disease. Long-term likely involves episodic reinvasion as well continuous infection, an extent that varies tissues. The primary reservoir sites humans not definitively known, analysis murine models has identified gastrointestinal tract. Here, we highlight quantitative, spatial, temporal aspects T. infection central fuller understanding association persistence, pathogenesis, immunity, for optimising treatment.