5'-methylpyrimidine and 2'-O-methyl ribonucleotide modified double-stranded ribonucleic acid molecules
作者： Lishan Chen , Kunyuan Cui , Mohammad Ahmadian , Steven Quay , Paul Johnson
DOI:
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摘要: The invention relates to a double-stranded RNA (dsRNA) molecule comprising between about 15 base pairs and 40 pairs, at least one 5′-methyl-pyrimidine 2′—O-methyl ribonucleotide, methods of using such modified dsRNA increase stability siRNA when in contact with biological sample, reduce off-target effects interferon responsiveness (IFN) the molecule.
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