Heterogeneity in striatal dopamine circuits: Form and function in dynamic reward seeking

摘要: The striatal dopamine system has long been studied in the context of reward learning, motivation, and movement. Given prominent role plays a variety adaptive behavioral states, as well diseases like addiction, it is essential to understand full complexity neurons systems they target. A growing number studies are uncovering details heterogeneity neuron subpopulations. Here, we review that work synthesize current understanding across three levels, anatomical organization, functions behavior, modes action, wherein focus on signaling profiles local mechanisms for modulation release. Together, these reveal new emerging dimensions system, informing its contribution dynamic motivational decision-making processes.