Molecular mechanisms of lead neurotoxicity

摘要: Epidemiological studies have shown a strong relationship between the level of lead in blood and bone as assessed by performance on IQ tests other psychometric tests. Approximately 1 out 10 children United States levels above 10μg/dl, which has been established concern. Studies experimental animals exposed to after birth learning deficits at similar levels. Since requires remodeling synapses brain, may specifically affect synaptic transmission. Although molecular targets for are unknown, vast amount evidence accumulated over many years that disrupts processes regulated calcium. Our laboratory studying effect protein kinase C, family isozymes some require calcium activity. We others picomolar concentrations can replace micromolar C enzyme assay. Furthermore, activates intact cells induces expression new genes mechanism dependent C. propose caused due events most likely occur synapse.