Postnatal development of corneal endothelium.

摘要: Comparison specular micrographs of infant and adult corneas from cats, cows, dogs, rabbits, humans demonstrate that a large decrease in central endothelial cell density occurs during maturation the cornea. Central counts developing cat, dog, rabbit rapidly first months life. This rapid decline correlates with growth cornea to size. cow, deer, pig, rabbit, human are similar (2500 cells/mm2) despite wide variation corneal observed two hypothetical situations, one unrestricted mitosis other only hypertrophy, indicates hypertrophy individual cells is primarily responsible for achieving 2500 cells/mm2 these species. observation true species have high mitotic capacity (rabbit) as well those do not (cat). The special case because apparent loss (approximately 45%) early postnatal development.