Expression and identification of olfactory receptors in sciatic nerve and dorsal root ganglia of rats
作者： Leilei Gong , Qianqian Chen , Xiaosong Gu , Shiying Li
DOI: 10.1016/J.NEULET.2015.06.019
关键词:
摘要: The olfactory receptor (OR) genes are expressed mainly in the cell membrane of sensory neurons nasal epithelium, and binding specific odorant ligands to OR proteins leads odor detection. ORs also non-olfactory tissues cells, but their functions often elusive. In this study, microarray analysis was used detect presence peripheral nerves. We found that a number were differentially sciatic nerve dorsal root ganglia (DRGs) following injury. expression profile several verified by situ hybridization real time quantitative RT-PCR. observed some primary culture Schwann cells up-regulated under H2O2 stimulation. Overall, all results suggest there may be possible relationship between differential injured nerves regeneration.
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sci-hub.se 参考文章(27)
Jasper Rine, Laurie Issel-Tarver, The Evolution of Mammalian Olfactory Receptor Genes Genetics. ,vol. 145, pp. 185- 195 ,(1997) , 10.1093/GENETICS/145.1.185
R. J. Pitts, C. Liu, X. Zhou, J. C. Malpartida, L. J. Zwiebel, Odorant receptor-mediated sperm activation in disease vector mosquitoes Proceedings of the National Academy of Sciences of the United States of America. ,vol. 111, pp. 2566- 2571 ,(2014) , 10.1073/PNAS.1322923111
Xinjing Luo, Baoguo Chen, Rui Zheng, Peng Lin, Jicheng Li, Haixiao Chen, Hydrogen peroxide induces apoptosis through the mitochondrial pathway in rat Schwann cells Neuroscience Letters. ,vol. 485, pp. 60- 64 ,(2010) , 10.1016/J.NEULET.2010.08.063
NaNa Kang, JaeHyung Koo, Olfactory receptors in non-chemosensory tissues Journal of Biochemistry and Molecular Biology. ,vol. 45, pp. 612- 622 ,(2012) , 10.5483/BMBREP.2012.45.11.232
Jennifer L. Pluznick, Ryan J. Protzko, Haykanush Gevorgyan, Zita Peterlin, Arnold Sipos, Jinah Han, Isabelle Brunet, La-Xiang Wan, Federico Rey, Tong Wang, Stuart J. Firestein, Masashi Yanagisawa, Jeffrey I. Gordon, Anne Eichmann, Janos Peti-Peterdi, Michael J. Caplan, Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation Proceedings of the National Academy of Sciences of the United States of America. ,vol. 110, pp. 4410- 4415 ,(2013) , 10.1073/PNAS.1215927110
B. Ansoleaga, P. Garcia-Esparcia, F. Llorens, J. Moreno, E. Aso, I. Ferrer, Dysregulation of brain olfactory and taste receptors in AD, PSP and CJD, and AD-related model Neuroscience. ,vol. 248, pp. 369- 382 ,(2013) , 10.1016/J.NEUROSCIENCE.2013.06.034
Y. Cao, B. C. Oh, L. Stryer, Cloning and localization of two multigene receptor families in goldfish olfactory epithelium Proceedings of the National Academy of Sciences of the United States of America. ,vol. 95, pp. 11987- 11992 ,(1998) , 10.1073/PNAS.95.20.11987
Joachim Freitag, Jürgen Krieger, Jörg Strotmann, Heinz Breer, Two classes of olfactory receptors in xenopus laevis Neuron. ,vol. 15, pp. 1383- 1392 ,(1995) , 10.1016/0896-6273(95)90016-0
Sufang Yang, Matthew S. Abrahams, Patricia D. Hurn, Marjorie R. Grafe, Jeffrey R. Kirsch, Local Anesthetic Schwann Cell Toxicity Is Time and Concentration Dependent Regional Anesthesia and Pain Medicine. ,vol. 36, pp. 444- 451 ,(2011) , 10.1097/AAP.0B013E318228C835
Tobias Maier, Marc Güell, Luis Serrano, Correlation of mRNA and protein in complex biological samples FEBS Letters. ,vol. 583, pp. 3966- 3973 ,(2009) , 10.1016/J.FEBSLET.2009.10.036