Lipid A Receptor TLR4-Mediated Signaling Pathways
作者： Masahiro Yamamoto , Shizuo Akira
DOI: 10.1007/978-1-4419-1603-7_6
关键词:
摘要: Lipid A is a strong activator of monocytes to release immune stimulators such as proinflammatory cytokines. Overproduction inflammatory cytokines TNF and IL-6 known cause septic shock that frequently leads multiple organ failure finally death. In recent years, has also been recognized by Toll-like receptor, TLR4. Activation TLR4by LPS or triggers signal transduction via the cytoplasmic domain called Toll/IL-1 Receptor (TIR) domain. Intracellular TIR domain-containing adaptor molecules are involved in TLR4-mediated signaling pathways. Moreover, subset LPS-inducible genes regulated two steps inducible nuclear protein. Additionally, activation cascadesis elaborately down-regulated number negative regulators. this chapter, we discuss mechanisms de-activation program mediated receptor
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