Epigenetics, stem cells and epithelial cell fate.
作者： Audrey Vincent , Isabelle Van Seuningen
DOI: 10.1016/J.DIFF.2009.07.002
关键词:
摘要: Establishment and maintenance of epigenetic profiles are essential steps development during which stem cells, despite identical genetic information, will acquire different selective gene expression patterns, specific for their fate. This highly complex programming process involves mechanisms that not yet completely understood although it has been established over the past few years chromatin modifier enzymes (i.e. DNA histone methyltransferases, deacetylases, demethylases, acetyltransferases) play roles in establishment transcriptional programs accompanying cell differentiation. Investigators this field have studying a wide variety types including neural, muscular, mesenchymal blood cells. review focus on epithelial cells digestive tract, intestinal niches being model choice to understand how changes can drive nuclear Moreover, deregulation is frequently observed human tumours therefore, decoding these molecular better both developmental cancerous processes.
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