Prospective study of body mass index, weight change, and risk of adult-onset asthma in women.

摘要: Background Obesity and asthma are common disorders, their prevalence rates continue to rise. Although individuals with may gain weight as a result of activity limitations, the relationship between body mass index (BMI), which is calculated in kilograms divided by square height meters, risk developing not known. Methods We performed prospective cohort study female US registered nurses Nurses' Health Study II. In 1991, after excluding women who died probable or incomplete data, there were 85,911 participants, aged 26 46 years. The main outcome measure was self-report physician-diagnosed recent use an medication. Results From 1991 1995, we identified 1596 incident cases asthma. multivariate model controlling for 9 potential confounding factors (including age, race, smoking, physical activity, energy intake), relative risks 6 increasing categories BMI 0.9, 1.0 (reference), 1.1, 1.6, 1.7, 2.7 ( P trend Conclusions has strong, independent, positive association adult-onset obesity developed nations help explain concomitant increases prevalence.