Triacylglycerol Storage and Mobilization, Regulation of
作者： G��nter M��ller , Stefan Petry ,
DOI: 10.1002/3527600906.MCB.200400165
关键词:
摘要: A growing number of enzymes that are involved in lipid metabolic pathways being identified and characterized. Here we summarize recent developments the understanding storage mobilization assess potential mechanisms as targets for pharmacological treatment disorders, noninsulin-dependent diabetes mellitus (NIDDM), obesity, syndrome. We focus on have been implicated biogenesis droplets their degradation (lipolysis) basis studies using (1) animal models overexpress or harbor targeted deletions genes encoding corresponding enzymes/proteins, (2) genetic and/or family NIDDM (3) modern biochemical/molecular biological methods identification functional analysis components metabolism. Keywords: Diabetes Mellitus; Hormone-sensitive Lipase; Insulin; Lipid Droplets; Lipolysis; Lipotoxicity; Translocation
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