Somnogenic cytokines and models concerning their effects on sleep.

摘要: Abstract All the sleep-promoting substances currently identified also have other biological activities. Despite years of effort, a single specific central nervous system sleep center has not been described. These observations led us to propose biochemical model activational in which effects several factors are integrated into regulatory scheme. interact by altering metabolism, production, or activity each and thereby result multiple feedback loops. This web interactions leads stability that minor challenges will greatly alter sleep. The system, however, is responsive strong perturbations, such as deprivation infectious disease. cytokines their with prostaglandins neuroendocrine used illustrate functioning part under normal conditions during Although actions individuals sleep, at various levels neuraxis can mediate response. Such would be autonomic environmental parameters