摘要: Deformations of DNA contribute to its essential biological function. In our laboratory, we have been studying both local and global deformations their relationship base sequence by molecular modeling simulation techniques. the current chapter, first give an overview various approaches used in laboratory build models control deformations. Notably, discuss JUMNA program that uses internal helicoidal variables, also umbrella sampling free energy simulations follow second part, summarize results these techniques enabled us obtain, starting from large scale deformations, such as stretching, twisting bending, down more changes involving opening flipping backbone conformations. A separate section deals with specific recognition proteins role deformation process. We hope show reader theoretical studies can play a significant obtaining better understanding this fascinating
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