Oxycodone. Pharmacological profile and clinical data in chronic pain management.

摘要: Opioids are widely used as effective analgesic therapy for cancer pain. Despite years of controversy, their use has been also accepted in chronic non-cancer Oxycodone alone and combination over 80 the treatment a variety pain syndromes. As single agent, controlled release (CR) oxycodone's market USA grew from 10% 1996 to 53% 2000 it become leading opioid United States. Recent data showed that fixed-combination oxycodone/acetaminophen (5 mg/325 mg) is most often prescribed across all different diagnoses. Compared with morphine, oxycodone higher oral bioavailability about twice potent. Pharmacokinetic-pharmacodynamic support pharmacologically active opiod does not require conversion oxymoprhone pharmacological activity. Seven studies addressed safety efficacy (low back pain, osteoarthritis painful diabetic neuropathy). Both immediate (IR) CR equally safe. Along these trials, mean daily dosage was approximately 40 mg, low incidence intolerable typical opiate side effects. In can be considered valid alternative morphine rotation. No difference between found. Controlled-release preparations, long duration action, attractive because they offer advantage longer dosing intervals sustained effect.