MDM2 overexpression is rare in ovarian carcinoma irrespective of TP53 mutation status.

摘要: Somatic mutations in TP53 are seen many human cancers. In addition, the protein product of wild-type can be sequestered by MDM2 (murine double minute 2). This is commonly overexpressed sarcomas and gliomas, usually as a result gene amplification. this study, 43 ovarian carcinomas (OCs) were analysed for aberrations immunohistochemistry (IHC), loss heterozygosity (LOH) or mutation analysis. The its was studied Southern blotting IHC. Over 50% OCs showed either direct sequencing (19/36, 53%), positive IHC (23,43, 53%) both, whereas 0/32 had amplification only 1/37 tumours using anti-MDM2 antibody IF-2. solitary example series mixed mullerian tumour with sarcomatous differentiation not accompanied DNA These results support previous data showing that around have suggest amplified OC, but presence features may