RNA expression profiles and regulatory networks in human right ventricular hypertrophy due to high pressure load.

摘要: Right ventricular hypertrophy (RVH) occurs in high pressure afterload, e.g., tetralogy of Fallot/pulmonary stenosis (TOF/PS). Such RVH is associated with alterations energy metabolism, neurohormonal and epigenetic dysregulation (e.g., microRNA), fetal gene reprogramming animal models. However, comprehensive expression profiling competing endogenous RNA human has not been performed. Here, we unravel several previously unknown circular, long non-coding, microRNAs, predicted to regulate genes specific the non-failing heart These are significantly overrepresented pathways related regulation glucose lipid metabolism (SIK1, FABP4), cell surface interactions (THBS2, FN1), apoptosis (PIK3IP1, SIK1), extracellular matrix composition (CTGF, IGF1), other biological events. This first unbiased sequencing study compensated encompassing coding non-coding sponging miRNAs by RNAs. findings advance our understanding adaptive highlight future therapeutic targets.