Differentiating the 2,3-diols of glucopyranosides by 4,6-O-benzylidene-protected-1,2-D-glucopyranosylorthoesters strategy.
作者： Guangfa Wang , Zhichao Lu , Ning Ding , Wei Zhang , Peng Wang
DOI: 10.1016/J.CARRES.2011.08.008
关键词:
摘要: Abstract A facile and efficient method to differentiate the 2,3-diols of glucopyranosides based on 1,2-orthoesters strategy was developed. Stable thioglucosides were employed as starting materials prepare corresponding 1,2-orthoesters. When treated with HCl aqueous solution followed Et 3 N, differentiation efficiently achieved along generation a convertible anomeric hydroxyl group. In addition, an easy practical NOE proposed determine whether endo -type or exo -type.
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