Magnetic Resonance Imaging Property of Doxorubicin-Loaded Gadolinium/13X Zeolite/Folic Acid Nanocomposite.
作者： S Ghaderi , B Divband , N Gharehaghaji
关键词:
摘要: Background Magnetic resonance imaging (MRI) using nanostructures has been a proper method for tumor targeting purposes. Different MRI nanomaterials, agents and anticancer drugs have used of tumors. Objectives This study aims to consider the property doxorubicin (DOX)-loaded gadolinium/13X zeolite/folic acid (Gd3+/13X/FA) nanocomposite.Material Methods In this in vitro study, Gd3+/13X/FA/DOX nanocomposite was prepared X-ray diffraction, scanning electron microscopy MTT assay were conducted evaluate physicochemical properties nanocomposite. performed at 25°C 1.5 T clinical system determine T1 relaxation times subsequently, relaxivity. Results The size range 80-200 nm. without DOX loading showed compatibility A549 cells all concentrations while DOX-loaded toxic 62% concentration 0.4 mg/ml. relaxivity 4.0401 mM-1s-1. Conclusion shows similar conventional gadolinium chelates, successful loading.
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