The Mitogen-Activated Protein Kinase Cascade Couples PKA and PKC to cAMP Response Element Binding Protein Phosphorylation in Area CA1 of Hippocampus

摘要: Activation of the mitogen-activated protein kinase (MAPK) cascade recently was discovered to play an important role in synaptic plasticity area CA1 rat hippocampus. However, upstream mechanisms regulating MAPK activity and downstream effectors hippocampus are uncharacterized. In present studies we observed that hippocampal activation is regulated by both PKA PKC systems; moreover, found a wide variety neuromodulatory neurotransmitter receptors (metabotropic glutamate receptors, muscarinic acetylcholine dopamine beta-adrenergic receptors) couple via these two cascades. additional powerful regulator CREB phosphorylation CA1. plays critical transcriptional regulation PKC, because necessary component for increased response this kinase. Surprisingly, also coupling Overall, indicate unexpected richness diversity suggest possibility broad gene expression long-term forms plasticity.