Tradeoff between risks through ingestion of nanoparticle contaminated water or fish: Human health perspective

摘要: Abstract This study proposed a framework (termed as “nanoHealthRisk” hereafter) for incorporating i) interaction of nanoparticles (NPs) with fishes, ii) availability NPs to the human digestive system, and iii) estimation health risk due fish consumption inadvertent ingestion NP-contaminated surface water, first time per literature review. The was applied estimating risks hypothetical exposures pristine ZnO, CuO, TiO2 (without any functionalization) from tissues. Values bio- concentration factors (BCF) in model distributions bio-assimilation factor CuO system were incorporated explicitly assessment time. ZnO NP observed be transferred more aqueous matrix than other two NPs. Maximum allowable values posing no found 0.115 mg/L, 0.152 mg/L, 1.77 × 107 mg/L NP, respectively. At environmental range, studied aquatic environment under assumptions used did not pose conditions this study. More work is required (1) Estimate bio-concentration mixture constituents tissues, (2) dissolution tissue media, (3) Generate new data develop reference dose assessment, (4) Study effect fate water on through pathway. Until all above-mentioned aspects are framework, estimates do represent completely. Thus, continuous monitoring these protect chronic exposure small concentrations an matrix.