HOVERGEN: a database of homologous vertebrate genes

摘要: Comparison of homologous genes is a major step for many studies related to genome structure, function or evolution. Similarity search programs easily find given sequence. However, only very tedious manual procedures allow the retrieval all sets sequenced set species. Moreover, this often generates errors due complexity data be managed simultaneously: phylogenetic trees, alignments, taxonomy, sequences and information. HOVERGEN helps solve these problems by integrating corresponds GenBank from vertebrate species, with some corrected, clarified, completed, notably address problem redundancy. Coding have been classified in gene families. Protein multiple alignments trees calculated each family. Sequences information structured an ACNUC database which permits complex selections. A graphical interface has developed visualize edit trees. Genes are displayed color, according their taxonomy. Users directly access attached simply clicking on genes. This tool gives thus rapid simple necessary interpret homology relationships between allows user select genes, particularly useful comparative sequence analysis, molecular evolution studies.