Targeting regulatory T cells with heterodimeric proteins
作者： Dilki Wickramarachchi , Matthew Bernett , Seung Chu , John Desjarlais
DOI:
关键词:
摘要: The present invention provides methods and compositions comprising a heterodimeric antibody first monomer variant heavy chain constant region an anti-CD4 binding moiety. also comprises second comprising: anti-CD25 In some cases, the pIs of regions are at least 0.5 logs apart.
lens.org参考文章(621)
Scott M Glaser, Stephen J Demarest, Antibody therapeutics, antibody engineering, and the merits of protein stability. Current Opinion in Drug Discovery & Development. ,vol. 11, pp. 675- ,(2008)
Von Kreudenstein Thomas Spreter, Gordon Yiu Kon Ng, Surjit Bhimarao Dixit, Nina E Weisser, Bispecific asymmetric heterodimers comprising anti-cd3 constructs ,(2013)
Theresa Martinez, Danielle Pace, Lowell Brady, Mary Gerhart, Alain Balland, Characterization of a novel modification on IgG2 light chain. Evidence for the presence of O-linked mannosylation. Journal of Chromatography A. ,vol. 1156, pp. 183- 187 ,(2007) , 10.1016/J.CHROMA.2007.04.050
S. Pessano, H. Oettgen, A.K. Bhan, C. Terhorst, The T3/T cell receptor complex: antigenic distinction between the two 20-kd T3 (T3-delta and T3-epsilon) subunits. The EMBO Journal. ,vol. 4, pp. 337- 344 ,(1985) , 10.1002/J.1460-2075.1985.TB03634.X
W.J. Mandy, A. Nisonoff, Effect of Reduction of Several Disulfide Bonds on the Properties and Recombination of Univalent Fragments of Rabbit Antibody Journal of Biological Chemistry. ,vol. 238, pp. 206- 213 ,(1963) , 10.1016/S0021-9258(19)83982-0
Wolfgang J. Rettig, John Edward Park, Olivier Lèger, Jose William Saldanha, Pilar Garin-Chesa, Uwe Bamberger, Fap.alpha.-specific antibody with improved producibility ,(1999)
Eiji Kobayashi, Satoru Nagamura, Nobuyoshi Amishiro, Katsushige Gomi, Akihiko Okamoto, Hiromitsu Saito, Pyrrolo-indole derivatives ,(1995)
Tomoyuki Igawa, Hiroyuki Tsunoda, Antibody modification method for purifying bispecific antibody ,(2007)
Paul A. Carpenter, Sandra Pavlovic, J. Y. Tso, Oliver W. Press, Theodore Gooley, Xue-Zhong Yu, Claudio Anasetti, Non-Fc receptor-binding humanized anti-CD3 antibodies induce apoptosis of activated human T cells. Journal of Immunology. ,vol. 165, pp. 6205- 6213 ,(2000) , 10.4049/JIMMUNOL.165.11.6205
Philip Tan, David A. Mitchell, Timothy N. Buss, Margaret A. Holmes, Claudio Anasetti, Jefferson Foote, “Superhumanized” Antibodies: Reduction of Immunogenic Potential by Complementarity-Determining Region Grafting with Human Germline Sequences: Application to an Anti-CD28 Journal of Immunology. ,vol. 169, pp. 1119- 1125 ,(2002) , 10.4049/JIMMUNOL.169.2.1119