The assimilation of amino acids by bacteria; the action of penicillin in preventing the assimilation of glutamic acid by Staphylococcus aureus.

摘要: SUMMARY: The effect on glutamic acid assimilation of the addition penicillin to growing cultures Staphylococcus aureus is described. When Staph, grown in media containing this substance accumulates steadily increasing concentration cells. medium followed after an interval by rapidly decreasing within normal washed cells not affected high concentration. which have presence impaired and may be completely inhibited. Complete inhibition brought about bactericidal concentrations penicillin, low requiring a longer time become effective than ones. loss assimilatory power can correlated with viability. Comparison general properties penicillin-inactivated show that respiration, glucose oxidation, fermentation lysine latter are normal. internal metabolism penicillin-treated cells, but, since passage across cell wall blocked, limited existing