Heart Mitochondrial ROS and Oxidative Stress

摘要: Under pathophysiological conditions, reactive oxygen species (ROS) levels may increase and cause cell damage dysfunction targeting primarily the mitochondria. Using an array of scavenging enzymes antioxidants, cardiomyocyte mainly its mitochondria can neutralize ROS. Importantly, besides damaging effect on cardiomyocytes, ROS play a central role in number signal transduction pathways. Whether effects this signaling are beneficial or harmful depend upon location, source, amount produced, as well overall redox status cell. Indeed, accurate delineation downstream pathways involved accumulation is important order to improve our understanding these processes also facilitate development novel therapies. In chapter, we will discuss how changes cellular state affect cardiac pathophysiology, current developing