Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes
作者： Geoffrey L Winsor , Thea Van Rossum , Raymond Lo , Bhavjinder Khaira , Matthew D Whiteside
DOI: 10.1093/NAR/GKN861
关键词:
摘要: Pseudomonas aeruginosa is a well-studied opportunistic pathogen that particularly known for its intrinsic antimicrobial resistance, diverse metabolic capacity, and ability to cause life threatening infections in cystic fibrosis patients. The Genome Database (http://www.pseudomonas.com) was originally developed as resource peer-reviewed, continually updated annotation the PAO1 reference strain genome. In order facilitate cross-strain cross-species genome comparisons with other species of importance, we have now expanded database capabilities include all species, or incorporated methods high quality comparative genomics. contains robust assessment orthologs, novel ortholog clustering method, incorporates five views data at sequence levels (Gbrowse, Mauve custom views) comparisons. A choice simple more flexible user-friendly Boolean search features allows researchers compare annotations sequences within between genomes. Other accurate protein subcellular localization predictions user-friendly, searchable log file updates PAO1. This aims continue provide quality, annotated research community available under an open source license.
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