Apolipoprotein E, Statins, and Risk of Intracerebral Hemorrhage
作者： Christopher D. Anderson , Joseph P. Broderick , Jonathan Rosand , Carl D. Langefeld , Jessica G. Woo
DOI: 10.1161/STROKEAHA.113.001304
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摘要: Background and Purpose—Apolipoprotein E (ApoE) genotypes have been associated with lobar intracerebral hemorrhage (ICH). Although statins an increased risk of ICH, meta-analyses not consistently shown a statin-induced ICH. Here, we test whether hypercholesterolemia (HC) ApoE polymorphisms affect the ICH by statin use. Methods—The Genetic Environmental Risk Factors for Hemorrhagic Stroke (GERFHS) study is prospective, demographically matched case–control A similar Risks Medication-Related (GOCHA), was used as replication cohort. Subjects were classified normocholesterolemia, HC without use, Statistical comparisons performed using Fisher exact test, χ2 tests, Breslow–Day test. Results—The discovery cohort consisted 558 cases 1444 controls, 1020 382 controls. The association lowe...
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