Intra-Articular Umbilical Cord Derived Mesenchymal Stem Cell Therapy for Chronic Elbow Osteoarthritis in Dogs: A Double-Blinded, Placebo-Controlled Clinical Trial

摘要: Background: Intra-articular stem cell therapy may help alleviate lameness caused by osteoarthritis in dogs. Umbilical cord-derived (UMSC) has not yet been investigated a veterinary clinical study. We hypothesized that dogs treated with intra-articular UMSC will have improved limb function and quality of life when compared to saline placebo injection. Methods: This was prospective, double-blinded, placebo-controlled trial client-owned chronic elbow follow-up time 6 months. Dogs were assigned receive (n = 38) or injection 30). Outcome measures included the Canine Brief Pain Inventory score (CBPI) peak vertical force (PVF) from force-platform gait analysis. Treatment considered successful there decrease Severity Score at least one Interference baseline. Success rates PVF between groups. Results: No adverse effects associated noted. Of completing study, treatment success 28) vs. groups 23) observed 54 28% 1 month, 50 27% 3 months, 46 14% respectively. rate group significantly higher than months after treatment. However, no differences affected over either group. Conclusions: for improve signs based on owner observations.