Prostate cancer racial, socioeconomic, geographic disparities: targeting the genomic landscape and splicing events in search for diagnostic, prognostic and therapeutic targets.

摘要: Prostate cancer (PCa) is one of the leading causes deaths in men globally. This a heterogeneous and complex disease that urgently warrants further insight into its pathology. Developed countries have thus far highest PCa incidence rates, with comparatively low mortality rates. Even though Asian population seems to high African are emerging as focal center for this disease. It has also been reported Sub-Saharan (SSA) both To date, few studies link between populations. Adequate evidence still missing fully comprehend relationship. While it brought attention racial, geographical socioeconomic status contributing factors, descent across globe, irrespective their position higher rates compared white counterparts. hormone therapy mainstay treatment PCa, while dysregulation androgen receptor (AR) signaling hallmark PCa. One problems therapeutic approach resistance antiandrogens, AR splice isoforms implicated progression lack ligand-binding domain (LBD) target. variants targeted clinical trials. Leveraging transcriptomics key towards precision medicine. The aim review outline epidemiology globally Africa, associated risk discuss mechanisms, role dysregulated splicing novel prognostic indicators targets.