Pharmacogenetics of adverse effects due to antiretroviral drugs.

摘要: The availability of highly active antiretroviral therapy has markedly improved the survival rate and quality life in patients infected with HIV. At present, however, there is still no cure for HIV those undergoing treatment have to do so life. use drugs been associated several toxicities that limit their success. Some acute chronic these include hypersensitivity reactions, neurotoxicity, nephropathy, liver damage, appearance body fat redistribution syndrome different metabolic alterations accompany it. are family- or even drug-specific. Since not all take a particular medication develop adverse effect attributed drug, it therefore postulated must be genetically conditioned individual predisposition developing effect. Pharmacogenetics science studies interindividual variations response toxicity pharmaceuticals due genetic composition individuals - other words, how person's make-up influences favorable effects certain treatment. Sufficient advances made this discipline allow fertile field research move out basic laboratory into clinical applications. present article reviews investigations published regarding association between determinants persons resulting from drugs. Special emphasis devoted resulted applications such as pre-screening HLA B*5701 avoiding abacavir-related syndrome.