Structure-Activity Relationships of Arodyn, a Novel Dynorphin A-(1–11) Analogue
作者： Marco A. Bennett , Thomas F. Murray , Jane V. Aldrich
DOI: 10.1007/978-94-010-0464-0_417
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摘要: The opioid receptors, mu (μ), kappa (κ) and delta (δ), are widely distributed throughout the peripheral central nervous system. When activated, receptors attenuate transmission of pain signals to spinal cord. Dynorphin A, an endogenous agonist at κ shares a common N-terminal “message” sequence (Tyr-Gly-Gly-Phe) with most mammalian peptides has unique C-terrninal “address” [1]. been reported be important for k activation, while is designated as potency-enhancing domain
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