Antimicrobial and hemolytic activities of copolymers with cationic and hydrophobic groups: a comparison of block and random copolymers.
作者： Yanqiang Wang , Junjuan Xu , Yueheng Zhang , Husheng Yan , Keliang Liu
关键词:
摘要: Random and diblock copolymers of 2-(N,N-dimethylamino)ethyl methacrylate butyl are prepared by ATRP. As mimics cationic antimicrobial peptides, the random show similar activities. In contrast, have much lower hemolytic activities than copolymers. The cell selectivity (HC(50)/MIC, where HC(50) is concentration to lyse 50% human red blood cells MIC minimum inhibit bacterial growth) 150 27,500 times higher that with compositions.
sci-hub.se 参考文章(39)
Edmund F. Palermo, Kenichi Kuroda, Chemical structure of cationic groups in amphiphilic polymethacrylates modulates the antimicrobial and hemolytic activities. Biomacromolecules. ,vol. 10, pp. 1416- 1428 ,(2009) , 10.1021/BM900044X
Karen Lienkamp, Ahmad E. Madkour, Ashlan Musante, Christopher F. Nelson, Klaus Nüsslein, Gregory N. Tew, Antimicrobial Polymers Prepared by ROMP with Unprecedented Selectivity: A Molecular Construction Kit Approach Journal of the American Chemical Society. ,vol. 130, pp. 9836- 9843 ,(2008) , 10.1021/JA801662Y
Husheng Yan, Shunzi Li, Xuejun Sun, Huaifeng Mi, Binglin He, Individual substitution analogs of Mel(12-26), melittin's C-terminal 15-residue peptide: their antimicrobial and hemolytic actions. FEBS Letters. ,vol. 554, pp. 100- 104 ,(2003) , 10.1016/S0014-5793(03)01113-X
Yuee Zhen, Shourong Wan, Yuanqin Liu, Husheng Yan, Rongfu Shi, Chunhong Wang, Atom transfer radical polymerization of solketal acrylate using cyclohexanone as the solvent Macromolecular Chemistry and Physics. ,vol. 206, pp. 607- 612 ,(2005) , 10.1002/MACP.200400414
Gregory N. Tew, Dylan Clements, Haizong Tang, Lachelle Arnt, Richard W. Scott, Antimicrobial activity of an abiotic host defense peptide mimic. Biochimica et Biophysica Acta. ,vol. 1758, pp. 1387- 1392 ,(2006) , 10.1016/J.BBAMEM.2006.03.001
Elisabeth Kreutzwiesner, Nadja Noormofidi, Frank Wiesbrock, Wolfgang Kern, Karl Rametsteiner, Franz Stelzer, Christian Slugovc, Contact bactericides and fungicides on the basis of amino‐functionalized poly(norbornene)s Journal of Polymer Science Part A. ,vol. 48, pp. 4504- 4514 ,(2010) , 10.1002/POLA.24241
Ronald Adelmann, Martina Mennicken, Dragos Popescu, Elisabeth Heine, Helmut Keul, Martin Moeller, Functional polymethacrylates as bacteriostatic polymers European Polymer Journal. ,vol. 45, pp. 3093- 3107 ,(2009) , 10.1016/J.EURPOLYMJ.2009.08.013
Shrinivas Venkataraman, Ying Zhang, Lihong Liu, Yi-Yan Yang, Design, syntheses and evaluation of hemocompatible pegylated-antimicrobial polymers with well-controlled molecular structures. Biomaterials. ,vol. 31, pp. 1751- 1756 ,(2010) , 10.1016/J.BIOMATERIALS.2009.11.030
Genghui Zhang, Baozhong Han, Xiaoyan Lin, Xin Wu, Husheng Yan, Modification of antimicrobial peptide with low molar mass poly(ethylene glycol). Journal of Biochemistry. ,vol. 144, pp. 781- 788 ,(2008) , 10.1093/JB/MVN134
Gregory J. Gabriel, Abhigyan Som, Ahmad E. Madkour, Tarik Eren, Gregory N. Tew, Infectious disease: Connecting innate immunity to biocidal polymers Materials Science & Engineering R-reports. ,vol. 57, pp. 28- 64 ,(2007) , 10.1016/J.MSER.2007.03.002