Oxidative lipidomics coming of age: advances in analysis of oxidized phospholipids in physiology and pathology.

摘要: Significance: Oxidized phospholipids are now well-recognized as markers of biological oxidative stress and bioactive molecules with both pro-inflammatory anti-inflammatory effects. While analytical methods continue to be developed for studies generic lipid oxidation, mass spectrometry (MS) has underpinned the advances in knowledge specific oxidized by allowing their identification characterization, is responsible expansion lipidomics. Recent Advances: Studies samples, from animal models clinical have been facilitated recent improvements MS, especially targeted routines that depend on fragmentation pattern parent molecular ion improved resolution accuracy. MS can used identify selectively individual compounds or groups common features, which greatly improves sensitivity specificity detection. Application these enabled important understanding mechanisms inflammatory diseases such atherosclerosis, steatohepatitis, leprosy cystic fibrosis, offer potential developing biomarkers aspects diseases. Critical Issues Future Directions: The future this field will development technologies, mobility, novel enrichment databases software data analysis, owing very large amount generated experiments. Imaging tissue an additional exciting direction emerging expected advance physiology disease.