Circulating Interleukin-6 Level, Dietary Antioxidant Capacity, and Risk of Colorectal Cancer
作者： Jimi Kim , Jeonghee Lee , Jae Hwan Oh , Hee Jin Chang , Dae Kyung Sohn
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摘要: Chronic inflammation is one of the causes colorectal cancer (CRC), and circulating levels inflammatory biomarkers have been linked to tumor promotion progression. We aimed evaluate interleukin-6 (IL-6) level in CRC patients determine whether a diet rich antioxidants was associated with CRC. This study included 654 cases 1312 controls matched for age sex. measured plasma IL-6 concentration estimated dietary antioxidant capacity based on oxygen radical absorbance (ORAC) combined 106-item semiquantitative food frequency questionnaire. The significantly increased individuals (OR Q4 vs. Q1, 95% CI = 6.23, 4.10-9.45, p < 0.001). High ORAC showed an inverse association (total OR 0.26, 0.16-0.40, 0.001; total phenolics 0.32, 0.21-0.50, found that low significant increase group elevated 4.34, 3.12-6.02, 4.61, 3.33-6.39, suggested between among
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