Association of blood mercury levels with nonmelanoma skin cancer in the U.S.A. using National Health and Nutrition Examination Survey data (2003-2016)

摘要: Background Some studies have reported increased incidence or mortality of lung and brain cancers associated with occupations involving potential mercury exposure. Epidemiological evidence related to skin cancer is also limited. Objectives To investigate the association between blood (Hg) levels nonmelanoma (NMSC). Methods We used National Health Nutrition Examination Survey data from 2003 2016. The exposures were total (tHg), inorganic (iHg) methylmercury (MeHg). outcome was a self-reported diagnosis NMSC. included participants aged ≥ 20 years who had information on sociodemographic factors. conducted logistic regression analysis estimate odds ratios (ORs) 95% confidence intervals (CIs) for risk NMSC quartiles Hg, after adjusting factors survey year. Results number 29 413; mean age 49 52% female. Compared those tHg ≤ 0·47 μg L-1 (Q1), > 1·74 (Q4) nearly double (OR 1·79, CI 1·19-2·71; Ptrend = 0·004). Similarly, in highest quartile MeHg (> 1·44 ) 1·7 times greater 1·74, 1·13-2·70; 0·01) than lowest (≤ 0·21 ). iHg nonsignificantly positively (Ptrend 0·08). Conclusions found that higher prevalence Linked Comment: Taylor. Br J Dermatol 2020; 183:413-414.