EM2487, a novel anti-HIV-1 antibiotic, produced by Streptomyces sp. Mer-2487: taxonomy, fermentation, biological properties, isolation and structure elucidation.
作者： HITOSHI TAKEUCHI , NAOKI ASAI , KAZUNORI TANABE , TERUYA KOZAKI , MASANORI FUJITA
DOI: 10.7164/ANTIBIOTICS.52.971
关键词:
摘要: For the purpose of discovering novel agents that inhibit HIV-1 replication at transcriptional level, we have established cell lines reflecting long terminal repeat-driven gene expression. Using these lines, screened approximately 10,000 microorganism products and found culture supernatant Streptomyces sp. Mer-2487 suppresses Tat-induced expression without affecting basal or tumor necrosis factor-alpha-induced transcription. The purified active component has a unique structure, as shown in Fig. 1. This compound an inhibitory effect on chronically infected cells well acutely cells, suggesting inhibition occurs postintegration step proviral DNA cycle.
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