Specific Polymorphisms in Hepatitis C Virus Genotype 3 Core Protein Associated with Intracellular Lipid Accumulation

作者: Ravi Jhaveri , John McHutchison , Keyur Patel , Guan Qiang , Anna Mae Diehl

DOI: 10.1086/524846

关键词:

摘要: Background Steatosis is a common histological finding and poor prognostic indicator in patients with hepatitis C virus (HCV) infection. In HCV genotype 3–infected patients, the etiology of steatosis appears to be closely correlated unknown viral factors that increase intracellular lipid levels. We hypothesize specific sequence polymorphisms 3 core protein may associated hepatic accumulation.

参考文章(43)
A.M. Gómez-Foix, W.S. Coats, S Baqué, T Alam, R.D. Gerard, C.B. Newgard, Adenovirus-mediated transfer of the muscle glycogen phosphorylase gene into hepatocytes confers altered regulation of glycogen metabolism. Journal of Biological Chemistry. ,vol. 267, pp. 25129- 25134 ,(1992) , 10.1016/S0021-9258(19)74015-0
J Cliff Yoon, Pere Puigserver, Guoxun Chen, Jerry Donovan, Zhidan Wu, James Rhee, Guillaume Adelmant, John Stafford, C Ronald Kahn, Daryl K Granner, Christopher B Newgard, Bruce M Spiegelman, None, Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature. ,vol. 413, pp. 131- 138 ,(2001) , 10.1038/35093050
Karim Abid, Valerio Pazienza, Andrea de Gottardi, Laura Rubbia-Brandt, Beatrice Conne, Paolo Pugnale, Christine Rossi, Alessandra Mangia, Francesco Negro, An in vitro model of hepatitis C virus genotype 3a-associated triglycerides accumulation. Journal of Hepatology. ,vol. 42, pp. 744- 751 ,(2005) , 10.1016/J.JHEP.2004.12.034
Manuel Romero-Gómez, Victor M Castellano-Megias, Lourdes Grande, José A Irles, Marina Cruz, Marí Carmen Nogales, Juan Carlos Alcón, Antonio Robles, Serum leptin levels correlate with hepatic steatosis in chronic hepatitis C The American Journal of Gastroenterology. ,vol. 98, pp. 1135- 1141 ,(2003) , 10.1016/S0002-9270(03)00185-0
Jie An, Deborah M Muoio, Masakazu Shiota, Yuka Fujimoto, Gary W Cline, Gerald I Shulman, Timothy R Koves, Robert Stevens, David Millington, Christopher B Newgard, Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance Nature Medicine. ,vol. 10, pp. 268- 274 ,(2004) , 10.1038/NM995
Arie Regev, Eugene R. Schiff, VIRAL HEPATITIS A, B, AND C Clinics in Liver Disease. ,vol. 4, pp. 47- 71 ,(2000) , 10.1016/S1089-3261(05)70096-9
Dinesh Kumar, Geoffrey C. Farrell, Caroline Fung, Jacob George, Hepatitis C virus genotype 3 is cytopathic to hepatocytes: Reversal of hepatic steatosis after sustained therapeutic response Hepatology. ,vol. 36, pp. 1266- 1272 ,(2002) , 10.1053/JHEP.2002.36370
Kyoji Moriya, Toru Todoroki, Takeya Tsutsumi, Hajime Fujie, Yoshizumi Shintani, Hideyuki Miyoshi, Kotaro Ishibashi, Tadatoshi Takayama, Masatoshi Makuuchi, Kiyoaki Watanabe, Tatsuo Miyamura, Satoshi Kimura, Kazuhiko Koike, Increase in the concentration of carbon 18 monounsaturated fatty acids in the liver with hepatitis C: analysis in transgenic mice and humans. Biochemical and Biophysical Research Communications. ,vol. 281, pp. 1207- 1212 ,(2001) , 10.1006/BBRC.2001.4523