Long-term results of high-dose chemotherapy and autologous stem cell rescue for high-risk neuroblastoma patients: a report of the Spanish working party for BMT in children (Getmon).

摘要: The authors retrospectively analyzed the long-term outcome of 67 patients over 1 year age at diagnosis with high-risk neuroblastoma (stage 4 or stage 3 N-myc amplification) who were treated megatherapy and stem cell rescue from 1984 to 1998. Median transplant was years (range 1.6–15 years). source cells peripheral in 29 bone marrow 38 patients. In 12 patients, an vitro purging harvest performed. Most conditioned melphalan, BCNU, VM-26. After 19 received complementary treatment IL-2 (16) 13-cis-retinoic acid (3). Six (8%) died transplant-related toxicity 39 disease progression. Three alive active time analysis. Nineteen are disease-free a median follow-up 104 months. Five-year event-free survival is 0.30. Survival purged graft not significantly better than rest. Post...