Effect of CYP2C19*17 gene variant on Helicobacter pylori eradication in peptic ulcer patients.

摘要: Objective Eradication of Helicobacter pylori is an important treatment strategy in peptic ulcer patients. Current regimens eradication consist proton pump inhibitor (PPI) and two antibiotics. The principal enzyme involved PPIs metabolism CYP2C19, which exhibits interindividual variability activity, mainly due to genetic polymorphism. Two alleles (CYP2C19*2 CYP2C19*3), responsible for slow metabolism, were previously associated with higher efficacy eradication. Recently, a novel CYP2C19 gene variant (CYP2C19*17), faster substrates, was described. In the present study, potential association between CYP2C19*17 allele lower H. tested group