Variability of Semiautomated Lung Nodule Volumetry on Ultralow-Dose CT: Comparison with Nodule Volumetry on Standard-Dose CT

摘要: The study investigates the effect of a substantial dose reduction on variability lung nodule volume measurements by assessing and comparing volumes using dedicated semiautomated segmentation software ultralow-dose computed tomography (ULD-CT) standard-dose (SD-CT) data. In 20 patients, thin-slice chest CT datasets (1 mm slice thickness; 20% reconstruction overlap) were acquired at (120 kV, 5 mAs) 75 mAs), respectively, analyzed OncoTREAT (MeVis, Bremen, Germany; version 1.3). Interobserver 202 solid pulmonary nodules (mean diameter 11 mm, range 3.2–44.5 mm) was calculated for SD-CT ULD-CT. With respect to interobserver variability, 95% confidence interval relative differences in intrascan analysis measured with −9.7% 8.3% difference −0.7%) −12.6% 12.4% −0.2%) interscan analysis, intervals ranged −25.1% −23.4% 26.2% 28.9% 1.4% 2.1%) dependent combination readers scans. Intrascan comparable ULD-CT similar data reported literature equal radiation dose. Thus, evaluated provides volumetry that appears be independent level which source dataset is acquired.