Halo-alkoxycarbonyl prodrugs
作者： Brent Blackburn , Alan G. Olivero , Kirk Robarge
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摘要: Halo-alkoxycarbonyl derivatives of formula (I) are provided as prodrug moieties for pharmaceutical agents containing a basic or polar nitrogen fucntionality. The prodrugs compositions well in methods treatment. A compound said wherein [(H)0-2(X)1-3] is selected from the group consisting X3, HX2, and H2X X2 halogen F, Cl, Br, I combination thereof; R?2 R3? same different H, C?1?-C4alkyl, C1-C4alkoxy, cyano, halo(F, I) C1-C4alkyl aryl, AG-Q biologically active agent Q N-containing functionality an amino, amidino, aminoalkyleneamino, iminoalkyleneamino, guanidino group.
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