One-Year Outcomes of Photodynamic Therapy in Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy in Japanese Patients

摘要: Purpose To determine the prevalence of polypoidal choroidal vasculopathy (PCV) in Japanese patients presumed to have age-related macular degeneration (AMD) and compare 1-year outcomes after photodynamic therapy between PCV neovascularization secondary AMD. Design Prospective interventional study. Participants Ninety-three consecutive (93 eyes) met inclusion criteria: at least 50 years old, best-corrected visual acuity (VA) 34 73 on Early Treatment Diabetic Retinopathy Study (ETDRS) letter chart, a subfoveal lesion 5400 μm or smaller greatest linear dimension (GLD) fluorescein angiography (FA), eligibility for therapy. Methods Indocyanine green was performed all participants, AMD were differentiated, treated with therapy, observed 1 year. The GLD determined by FA indocyanine PCV, diameter laser spot size chosen, an extra 1000 added GLD. Photodynamic repeated if leakage occurred 3-month follow-up visits. Main Outcome Measures Prevalence baseline angiographic changes year Results Using angiography, 36 eyes (39%) diagnosed 54 (58%) median change VA using ETDRS score from −7.0 +8.0 (Mann–Whitney rank sum test; P = 0.031). Polypoidal recurred 2 (5.6%), new developed eye (2.8%) (3.7%) Conclusion meeting treatment criteria is high patients. more efficacious than AMD, which may explain good results Further study should assess long-term clinical results.