Lysophosphatidic acid (LPA) signalling in cell migration and cancer invasion: A focussed review and analysis of LPA receptor gene expression on the basis of more than 1700 cancer microarrays
作者： Semjon Willier , Elke Butt , Thomas G. P. Grunewald
关键词:
摘要: Lysophosphatidic acid (LPA) is a ubiquitously present signalling molecule involved in diverse cellular processes such as cell migration, proliferation and differentiation. LPA acts an autocrine and/or paracrine via different G-protein-coupled receptors (LPARs) that trigger broad range of intracellular cascades, especially the RHOA pathway. Mounting evidence suggests crucial role LPA/LPAR-axis cancer metastasis promising studies are underway to investigate therapeutic potential LPAR-antagonists. This review summarises current knowledge on how promotes cytoskeletal remodelling enhance migratory invasive properties cells, which may ultimately contribute metastasis. Furthermore, we provide comprehensive transcriptome analyses published microarrays more than 350 normal tissues 1700 malignant define expression signatures LPARs LPA-generating enzymes autotaxin (ATX) lipase member 1 (LIPI). These demonstrate ATX highly expressed variety carcinomas sarcomas, whereas LIPI almost exclusively overexpressed aggressive Ewing's underscores contribution metastatic disease. In addition, these show entities display distinct distinguish them from one another. Finally, discuss approaches specifically target LPA/LPAR circuits experimental therapy.
sci-hub.se 参考文章(105)
Fumio Imamura, Mutsuko Mukai, Masako Ayaki, Koichi Takemura, Takeshi Horai, Kiyoko Shinkai, Hiroyuki Nakamura, Hitoshi Akedo, Involvement of small GTPases Rho and Rac in the invasion of rat ascites hepatoma cells. Clinical & Experimental Metastasis. ,vol. 17, pp. 141- 148 ,(1999) , 10.1023/A:1006598531238
Sylvain G Bourgoin, Chenqi Zhao, Autotaxin and lysophospholipids in rheumatoid arthritis. Current opinion in investigational drugs. ,vol. 11, pp. 515- ,(2010)
Neveen A. Said, Ahmed A. Elmarakby, John D. Imig, David J. Fulton, Kouros Motamed, SPARC ameliorates ovarian cancer-associated inflammation Neoplasia. ,vol. 10, pp. 1092- 1104 ,(2008) , 10.1593/NEO.08672
Masakazu Hirakawa, Masahiro Oike, Yuji Karashima, Yushi Ito, Sequential activation of RhoA and FAK/paxillin leads to ATP release and actin reorganization in human endothelium. The Journal of Physiology. ,vol. 558, pp. 479- 488 ,(2004) , 10.1113/JPHYSIOL.2004.065334
Tetsuji Mutoh, Richard Rivera, Jerold Chun, Insights into the pharmacological relevance of lysophospholipid receptors British Journal of Pharmacology. ,vol. 165, pp. 829- 844 ,(2012) , 10.1111/J.1476-5381.2011.01622.X
M L Stracke, H C Krutzsch, E J Unsworth, A Arestad, V Cioce, E Schiffmann, L A Liotta, Identification, Purification, and Partial Sequence Analysis of Autotaxin, a Novel Motility-stimulating Protein* Journal of Biological Chemistry. ,vol. 267, pp. 2524- 2529 ,(1992) , 10.1016/S0021-9258(18)45911-X
M Takamura, Inhibition of intrahepatic metastasis of human hepatocellular carcinoma by Rho-associated protein kinase inhibitor Y-27632☆ Hepatology. ,vol. 33, pp. 577- 581 ,(2001) , 10.1053/JHEP.2001.22652
Fumio Imamura, Kiyoko Shinkai, Mutsuko Mukai, Kiyoko Yoshioka, Rika Komagome, Teruo Iwasaki, Hitoshi Akedo, rho-Mediated protein tyrosine phosphorylation in lysophosphatidic-acid-induced tumor-cell invasion. International Journal of Cancer. ,vol. 65, pp. 627- 632 ,(1996) , 10.1002/(SICI)1097-0215(19960301)65:5<627::AID-IJC12>3.0.CO;2-4
Marc CM van Dijk, Friso Postma, Henk Hilkmann, Kees Jalink, Wim J van Blitterswijk, Wouter H. Moolenaar, Exogenous phospholipase D generates Iysophosphatidic acid and activates Ras, Rho and Ca2+ signaling pathways Current Biology. ,vol. 8, pp. 386- 392 ,(1998) , 10.1016/S0960-9822(98)70157-5
Honglu Zhang, Xiaoyu Xu, Joanna Gajewiak, Ryoko Tsukahara, Yuko Fujiwara, Jianxiong Liu, James I. Fells, Donna Perygin, Abby L. Parrill, Gabor Tigyi, Glenn D. Prestwich, Dual Activity Lysophosphatidic Acid Receptor Pan-Antagonist/Autotaxin Inhibitor Reduces Breast Cancer Cell Migration In vitro and Causes Tumor Regression In vivo Cancer Research. ,vol. 69, pp. 5441- 5449 ,(2009) , 10.1158/0008-5472.CAN-09-0302