A Central Role for DNA Replication Forks in Checkpoint Activation and Response
作者： José Antonio Tercero , Maria Pia Longhese , John F.X Diffley
DOI: 10.1016/S1097-2765(03)00169-2
关键词:
摘要: The checkpoint proteins Rad53 and Mec1-Ddc2 regulate many aspects of cell metabolism in response to DNA damage. We have examined the relative importance downstream effectors on viability. Checkpoint regulation mitosis, gene expression, late origin firing make only modest contributions By contrast, is essential for preventing irreversible breakdown stalled replication forks. Moreover, recruitment Ddc2 nuclear foci subsequent activation kinase occur during S phase require assembly Thus, forks are both activators primary pathway phase.
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